Predicted to enable lipid binding activity. Predicted to be involved in signal transduction and sphingolipid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TEX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:63,998,051–63,998,826 | 264.9 kb | Distal (>10kb) Multiome | 408 | |
| chr17:64,129,318–64,130,921 | 133.0 kb | Distal (>10kb) Multiome | 978 | |
| chr17:64,145,473–64,147,600 | 117.3 kb | Distal (>10kb) Multiome | 1196 | |
| chr17:64,262,431–64,263,974 | 123 bp | At TSS Multiome | 914 | |
| chr17:64,470,609–64,471,086 | 207.6 kb | Distal (>10kb) Multiome | 39 | |
| chr17:64,496,498–64,497,782 | 233.9 kb | Distal (>10kb) Multiome | 1074 | |
| chr17:64,504,990–64,507,698 | 242.1 kb | Distal (>10kb) Multiome | 1232 |
Genomic view of the TEX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.