Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TESMIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TESMIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TESMIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:68,459,835–68,461,497 | 290.1 kb | Distal (>10kb) Multiome | 1017 | |
| chr11:68,683,947–68,685,063 | 66.0 kb | Distal (>10kb) Multiome | 317 | |
| chr11:68,749,819–68,752,106 | 888 bp | At TSS Multiome | 601 | |
| chr11:68,839,165–68,839,925 | 88.8 kb | Distal (>10kb) Multiome | 821 | |
| chr11:68,840,765–68,842,245 | 91.3 kb | Distal (>10kb) Multiome | 567 | |
| chr11:68,843,712–68,844,382 | 93.4 kb | Distal (>10kb) Multiome | 675 | |
| chr11:68,855,267–68,855,945 | 104.9 kb | Distal (>10kb) Multiome | 230 | |
| chr11:68,879,344–68,879,843 | 128.9 kb | Distal (>10kb) Multiome | 69 | |
| chr11:68,903,762–68,904,282 | 153.3 kb | Distal (>10kb) Multiome | 1004 | |
| chr11:69,010,998–69,011,634 | 260.6 kb | Distal (>10kb) Multiome | 255 | |
| chr11:69,013,121–69,013,629 | 262.9 kb | Distal (>10kb) Multiome | 143 | |
| chr11:69,048,479–69,049,470 | 298.3 kb | Distal (>10kb) Multiome | 583 |
Genomic view of the TESMIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.