This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
Transcription factors with Perturb-seq knockdown data for TCTN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCTN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCTN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:95,425,771–95,426,669 | 267.7 kb | Distal (>10kb) Multiome | 202 | |
| chr10:95,560,414–95,561,730 | 132.5 kb | Distal (>10kb) Multiome | 707 | |
| chr10:95,655,874–95,657,154 | 37.2 kb | Distal (>10kb) Multiome | 834 | |
| chr10:95,693,285–95,694,389 | 145 bp | At TSS Multiome | 744 | |
| chr10:95,840,547–95,841,469 | 147.0 kb | Distal (>10kb) Multiome HiCAR | 21 | |
| chr10:95,907,059–95,908,292 | 214.0 kb | Distal (>10kb) Multiome | 823 | |
| chr10:95,920,289–95,921,295 | 226.7 kb | Distal (>10kb) Multiome | 99 |
Genomic view of the TCTN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.