Involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Located in several cellular components, including apical cortex; cytoskeleton; and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TCHP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCHP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCHP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:109,679,688–109,680,306 | 220.2 kb | Distal (>10kb) Multiome | 69 | |
| chr12:109,697,996–109,698,635 | 202.0 kb | Distal (>10kb) Multiome | 115 | |
| chr12:109,713,288–109,715,156 | 186.5 kb | Distal (>10kb) Multiome | 793 | |
| chr12:109,717,933–109,718,896 | 181.7 kb | Distal (>10kb) Multiome | 199 | |
| chr12:109,737,442–109,738,212 | 162.4 kb | Distal (>10kb) Multiome | 231 | |
| chr12:109,739,699–109,741,057 | 160.1 kb | Distal (>10kb) Multiome | 245 | |
| chr12:109,833,102–109,833,778 | 66.8 kb | Distal (>10kb) Multiome | 217 | |
| chr12:109,845,155–109,845,762 | 54.8 kb | Distal (>10kb) Multiome | 618 | |
| chr12:109,880,019–109,881,173 | 19.7 kb | Distal (>10kb) Multiome | 576 | |
| chr12:109,900,106–109,900,747 | 51 bp | At TSS Multiome HiCAR | 818 | |
| chr12:109,901,092–109,901,259 | 819 bp | At TSS | 127 | |
| chr12:109,995,726–109,996,660 | 96.0 kb | Distal (>10kb) Multiome | 811 | |
| chr12:109,998,999–109,999,838 | 99.0 kb | Distal (>10kb) Multiome | 883 | |
| chr12:110,048,083–110,048,797 | 148.3 kb | Distal (>10kb) Multiome | 921 | |
| chr12:110,107,883–110,108,523 | 207.9 kb | Distal (>10kb) Multiome | 171 | |
| chr12:110,123,690–110,124,996 | 224.1 kb | Distal (>10kb) Multiome | 704 |
Genomic view of the TCHP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.