Transcription factors with Perturb-seq knockdown data for TCF12-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCF12-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCF12-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:56,464,770–56,465,573 | 453.4 kb | Distal (>10kb) Multiome HiCAR | 565 | |
| chr15:56,732,731–56,733,957 | 185.0 kb | Distal (>10kb) Multiome | 919 | |
| chr15:56,758,979–56,759,508 | 159.3 kb | Distal (>10kb) Multiome | 183 | |
| chr15:56,886,886–56,888,067 | 31.2 kb | Distal (>10kb) Multiome | 1086 | |
| chr15:56,917,829–56,920,157 | 17 bp | At TSS Multiome | 1031 | |
| chr15:57,198,642–57,199,172 | 280.4 kb | Distal (>10kb) Multiome | 193 |
Genomic view of the TCF12-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.