The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein. This gene also encodes a domain with similarity to the transcription elongation factor A, SII-related family. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TCEAL9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCEAL9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCEAL9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,101,365–103,102,296 | 254.6 kb | Distal (>10kb) Multiome | 252 | |
| chrX:103,214,792–103,216,027 | 141.4 kb | Distal (>10kb) Multiome | 433 | |
| chrX:103,254,119–103,255,539 | 101.1 kb | Distal (>10kb) Multiome | 553 | |
| chrX:103,310,557–103,311,346 | 45.5 kb | Distal (>10kb) Multiome | 289 | |
| chrX:103,356,319–103,356,767 | at TSS | At TSS | 290 | |
| chrX:103,376,152–103,376,747 | 19.9 kb | Distal (>10kb) Multiome | 356 | |
| chrX:103,431,896–103,432,874 | 75.9 kb | Distal (>10kb) Multiome | 6 | |
| chrX:103,607,566–103,608,355 | 251.5 kb | Distal (>10kb) Multiome | 234 |
Genomic view of the TCEAL9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.