This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TCEAL8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCEAL8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCEAL8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,101,365–103,102,296 | 153.3 kb | Distal (>10kb) Multiome | 252 | |
| chrX:103,214,792–103,216,027 | 40.0 kb | Distal (>10kb) Multiome | 433 | |
| chrX:103,253,759–103,253,905 | 1.2 kb | Proximal (<10kb) | 97 | |
| chrX:103,254,119–103,255,539 | 209 bp | At TSS Multiome | 553 | |
| chrX:103,310,557–103,311,346 | 55.9 kb | Distal (>10kb) Multiome | 289 | |
| chrX:103,376,152–103,376,747 | 121.2 kb | Distal (>10kb) Multiome | 356 | |
| chrX:103,431,896–103,432,874 | 177.2 kb | Distal (>10kb) Multiome HiCAR | 6 |
Genomic view of the TCEAL8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.