The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TCEA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCEA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCEA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:63,775,216–63,775,997 | 287.7 kb | Distal (>10kb) Multiome | 257 | |
| chr20:63,830,341–63,832,721 | 231.9 kb | Distal (>10kb) Multiome | 628 | |
| chr20:63,846,273–63,846,790 | 216.7 kb | Distal (>10kb) Multiome | 487 | |
| chr20:63,864,234–63,865,991 | 198.1 kb | Distal (>10kb) Multiome | 1158 | |
| chr20:63,894,341–63,895,764 | 168.2 kb | Distal (>10kb) Multiome | 791 | |
| chr20:63,938,191–63,939,815 | 124.5 kb | Distal (>10kb) Multiome | 287 | |
| chr20:63,939,918–63,942,008 | 121.6 kb | Distal (>10kb) Multiome | 496 | |
| chr20:63,955,375–63,956,875 | 106.8 kb | Distal (>10kb) Multiome | 1107 | |
| chr20:63,956,976–63,958,127 | 105.5 kb | Distal (>10kb) Multiome | 709 | |
| chr20:63,969,149–63,970,667 | 93.2 kb | Distal (>10kb) Multiome | 764 | |
| chr20:63,973,660–63,974,150 | 89.2 kb | Distal (>10kb) Multiome | 767 | |
| chr20:63,980,541–63,981,488 | 82.0 kb | Distal (>10kb) Multiome | 986 | |
| chr20:64,030,226–64,031,221 | 32.4 kb | Distal (>10kb) Multiome | 159 | |
| chr20:64,038,338–64,039,469 | 24.1 kb | Distal (>10kb) Multiome | 628 | |
| chr20:64,047,989–64,049,987 | 13.7 kb | Distal (>10kb) Multiome | 541 | |
| chr20:64,053,902–64,054,682 | 8.9 kb | Proximal (<10kb) Multiome | 609 | |
| chr20:64,057,481–64,058,099 | 5.3 kb | Proximal (<10kb) Multiome | 659 | |
| chr20:64,062,561–64,063,881 | 105 bp | At TSS Multiome | 991 | |
| chr20:64,069,793–64,069,976 | 6.6 kb | Proximal (<10kb) | 307 | |
| chr20:64,079,311–64,080,472 | 16.7 kb | Distal (>10kb) Multiome | 688 | |
| chr20:64,083,392–64,084,408 | 20.5 kb | Distal (>10kb) Multiome | 591 | |
| chr20:64,101,897–64,102,924 | 39.1 kb | Distal (>10kb) Multiome | 457 | |
| chr20:64,160,199–64,160,889 | 97.3 kb | Distal (>10kb) Multiome | 55 | |
| chr20:64,255,171–64,256,183 | 192.4 kb | Distal (>10kb) Multiome | 861 |
Genomic view of the TCEA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.