Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TC2N. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TC2N upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TC2N, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:91,830,911–91,831,102 | 5.4 kb | Proximal (<10kb) | 76 | |
| chr14:91,834,655–91,834,864 | 1.7 kb | Proximal (<10kb) | 17 | |
| chr14:91,835,675–91,837,066 | 48 bp | At TSS Multiome | 412 | |
| chr14:91,947,236–91,948,135 | 111.2 kb | Distal (>10kb) Multiome | 316 | |
| chr14:92,039,326–92,040,502 | 203.5 kb | Distal (>10kb) Multiome | 937 | |
| chr14:92,105,904–92,107,104 | 270.1 kb | Distal (>10kb) Multiome | 794 | |
| chr14:92,121,241–92,122,514 | 285.3 kb | Distal (>10kb) Multiome | 838 |
Genomic view of the TC2N locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.