Enables RNA binding activity. Involved in mitochondrial mRNA processing and regulation of mitochondrial mRNA stability. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBRG4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBRG4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBRG4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:44,847,376–44,848,800 | 263.5 kb | Distal (>10kb) Multiome | 990 | |
| chr7:44,884,668–44,886,169 | 226.1 kb | Distal (>10kb) Multiome | 956 | |
| chr7:44,962,460–44,963,298 | 148.8 kb | Distal (>10kb) Multiome HiCAR | 179 | |
| chr7:44,986,037–44,987,077 | 125.0 kb | Distal (>10kb) Multiome HiCAR | 748 | |
| chr7:44,999,127–45,000,858 | 111.7 kb | Distal (>10kb) Multiome | 706 | |
| chr7:45,051,984–45,052,624 | 59.4 kb | Distal (>10kb) Multiome | 90 | |
| chr7:45,088,228–45,089,744 | 22.5 kb | Distal (>10kb) Multiome | 375 | |
| chr7:45,111,371–45,112,159 | 84 bp | At TSS Multiome | 1026 | |
| chr7:45,259,911–45,260,671 | 148.5 kb | Distal (>10kb) Multiome | 265 |
Genomic view of the TBRG4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.