This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for TBPL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBPL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBPL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:133,654,160–133,655,082 | 298.6 kb | Distal (>10kb) Multiome | 90 | |
| chr6:133,837,635–133,838,474 | 115.2 kb | Distal (>10kb) Multiome | 508 | |
| chr6:133,888,652–133,890,259 | 64.2 kb | Distal (>10kb) Multiome | 323 | |
| chr6:133,891,167–133,891,948 | 61.6 kb | Distal (>10kb) Multiome | 305 | |
| chr6:133,916,620–133,917,311 | 36.4 kb | Distal (>10kb) Multiome | 344 | |
| chr6:133,951,916–133,953,876 | 48 bp | At TSS Multiome | 1096 | |
| chr6:134,052,117–134,053,097 | 99.4 kb | Distal (>10kb) Multiome | 520 | |
| chr6:134,074,125–134,074,941 | 121.3 kb | Distal (>10kb) Multiome HiCAR | 190 | |
| chr6:134,173,985–134,177,008 | 221.8 kb | Distal (>10kb) Multiome | 1094 | |
| chr6:134,178,107–134,178,954 | 225.3 kb | Distal (>10kb) Multiome | 484 | |
| chr6:134,902,167–134,902,866 | 949.2 kb | Distal (>10kb) Multiome HiCAR | 91 |
Genomic view of the TBPL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.