The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for TBCA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBCA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBCA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:77,491,730–77,492,869 | 284.0 kb | Distal (>10kb) Multiome | 905 | |
| chr5:77,629,708–77,631,041 | 146.0 kb | Distal (>10kb) Multiome | 548 | |
| chr5:77,638,449–77,639,477 | 137.4 kb | Distal (>10kb) Multiome | 181 | |
| chr5:77,750,907–77,751,280 | 25.1 kb | Distal (>10kb) Multiome | 37 | |
| chr5:77,775,064–77,776,789 | 26 bp | At TSS Multiome | 867 | |
| chr5:77,781,125–77,781,620 | 5.0 kb | Proximal (<10kb) Multiome | 87 | |
| chr5:77,844,074–77,844,915 | 68.0 kb | Distal (>10kb) Multiome | 132 | |
| chr5:77,847,781–77,848,281 | 71.8 kb | Distal (>10kb) Multiome | 154 | |
| chr5:77,852,519–77,853,002 | 76.4 kb | Distal (>10kb) Multiome HiCAR | 349 | |
| chr5:77,957,955–77,958,500 | 181.8 kb | Distal (>10kb) Multiome | 325 |
Genomic view of the TBCA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.