Enables AP-2 adaptor complex binding activity and retromer complex binding activity. Involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Located in several cellular components, including Atg1/ULK1 kinase complex; autophagosome; and cytoplasmic vesicle membrane. Part of retromer complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBC1D5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:17,536,527–17,537,277 | 205.7 kb | Distal (>10kb) Multiome | 69 | |
| chr3:17,741,727–17,743,491 | 115 bp | At TSS Multiome | 1058 | |
| chr3:17,745,386–17,745,580 | 2.8 kb | Proximal (<10kb) | 20 | |
| chr3:17,840,550–17,841,652 | 98.7 kb | Distal (>10kb) Multiome | 408 | |
| chr3:17,846,059–17,847,000 | 104.0 kb | Distal (>10kb) Multiome | 65 | |
| chr3:18,018,594–18,019,918 | 276.6 kb | Distal (>10kb) Multiome | 282 |
Genomic view of the TBC1D5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.