Enables molecular adaptor activity. Involved in cilium assembly. Located in Golgi apparatus; centriolar satellite; and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBC1D31. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D31 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D31, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:122,780,039–122,780,999 | 292.3 kb | Distal (>10kb) Multiome | 860 | |
| chr8:122,781,087–122,783,557 | 289.6 kb | Distal (>10kb) Multiome | 793 | |
| chr8:122,837,253–122,838,328 | 234.8 kb | Distal (>10kb) Multiome | 291 | |
| chr8:123,041,536–123,042,890 | 30.4 kb | Distal (>10kb) Multiome | 925 | |
| chr8:123,065,582–123,066,386 | 6.6 kb | Proximal (<10kb) Multiome | 354 | |
| chr8:123,072,367–123,073,561 | 62 bp | At TSS Multiome | 858 | |
| chr8:123,156,604–123,157,953 | 84.6 kb | Distal (>10kb) Multiome | 1083 | |
| chr8:123,160,441–123,161,547 | 88.0 kb | Distal (>10kb) Multiome | 590 | |
| chr8:123,205,121–123,205,789 | 132.7 kb | Distal (>10kb) Multiome | 298 | |
| chr8:123,207,081–123,207,716 | 134.7 kb | Distal (>10kb) Multiome | 96 | |
| chr8:123,235,684–123,236,295 | 163.3 kb | Distal (>10kb) Multiome | 110 | |
| chr8:123,240,791–123,241,581 | 168.6 kb | Distal (>10kb) Multiome | 784 | |
| chr8:123,273,286–123,275,625 | 202.0 kb | Distal (>10kb) Multiome | 970 |
Genomic view of the TBC1D31 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.