Enables 14-3-3 protein binding activity. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBC1D22B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D22B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D22B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:36,985,740–36,986,913 | 271.4 kb | Distal (>10kb) Multiome | 926 | |
| chr6:37,051,534–37,052,487 | 206.1 kb | Distal (>10kb) Multiome | 766 | |
| chr6:37,059,338–37,060,100 | 198.1 kb | Distal (>10kb) Multiome | 824 | |
| chr6:37,071,640–37,072,385 | 185.9 kb | Distal (>10kb) Multiome | 281 | |
| chr6:37,102,284–37,103,074 | 155.1 kb | Distal (>10kb) Multiome | 855 | |
| chr6:37,125,557–37,126,783 | 131.7 kb | Distal (>10kb) Multiome | 528 | |
| chr6:37,137,028–37,138,409 | 120.0 kb | Distal (>10kb) Multiome | 735 | |
| chr6:37,141,368–37,141,988 | 116.1 kb | Distal (>10kb) Multiome | 239 | |
| chr6:37,168,853–37,171,673 | 87.8 kb | Distal (>10kb) Multiome | 1096 | |
| chr6:37,172,048–37,172,496 | 85.4 kb | Distal (>10kb) Multiome | 818 | |
| chr6:37,221,712–37,222,953 | 35.1 kb | Distal (>10kb) Multiome | 747 | |
| chr6:37,257,338–37,258,482 | 5 bp | At TSS Multiome | 890 | |
| chr6:37,319,150–37,319,973 | 61.8 kb | Distal (>10kb) Multiome | 54 | |
| chr6:37,353,783–37,354,458 | 96.2 kb | Distal (>10kb) Multiome | 794 | |
| chr6:37,432,813–37,433,740 | 175.5 kb | Distal (>10kb) Multiome | 901 | |
| chr6:37,484,079–37,484,645 | 226.6 kb | Distal (>10kb) Multiome | 222 | |
| chr6:37,499,465–37,500,524 | 242.2 kb | Distal (>10kb) Multiome | 714 |
Genomic view of the TBC1D22B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.