Predicted to enable GTPase activator activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBC1D19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:26,318,840–26,321,924 | 264.6 kb | Distal (>10kb) Multiome | 1097 | |
| chr4:26,583,577–26,584,548 | 73 bp | At TSS Multiome | 965 | |
| chr4:26,857,192–26,858,131 | 273.6 kb | Distal (>10kb) Multiome | 772 | |
| chr4:26,859,867–26,862,050 | 276.6 kb | Distal (>10kb) Multiome | 911 |
Genomic view of the TBC1D19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.