This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Transcription factors with Perturb-seq knockdown data for TBC1D15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:71,662,923–71,664,744 | 175.7 kb | Distal (>10kb) Multiome | 1029 | |
| chr12:71,671,386–71,672,338 | 167.8 kb | Distal (>10kb) Multiome | 185 | |
| chr12:71,685,622–71,686,597 | 153.5 kb | Distal (>10kb) Multiome | 910 | |
| chr12:71,754,180–71,755,575 | 84.9 kb | Distal (>10kb) Multiome | 892 | |
| chr12:71,839,299–71,840,331 | 24 bp | At TSS Multiome | 972 | |
| chr12:71,938,597–71,939,301 | 99.2 kb | Distal (>10kb) Multiome | 651 | |
| chr12:71,947,591–71,948,143 | 108.2 kb | Distal (>10kb) Multiome | 370 |
Genomic view of the TBC1D15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.