This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for TAX1BP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAX1BP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAX1BP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:27,448,884–27,449,537 | 290.9 kb | Distal (>10kb) Multiome | 94 | |
| chr7:27,662,196–27,663,278 | 77.1 kb | Distal (>10kb) Multiome | 918 | |
| chr7:27,739,539–27,741,150 | 65 bp | At TSS Multiome | 940 | |
| chr7:27,745,152–27,745,356 | 5.0 kb | Proximal (<10kb) | 285 | |
| chr7:28,005,426–28,006,357 | 265.7 kb | Distal (>10kb) Multiome | 128 |
Genomic view of the TAX1BP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.