TARS2

threonyl-tRNA synthetase 2, mitochondrial | FLJ12528, TARSL1

This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]

Biological processes 18 terms

ATP binding (GO:0005524)aminoacyl-tRNA deacylase activity (GO:0002161)aminoacyl-tRNA ligase activity (GO:0004812)aminoacyl-tRNA metabolism involved in translational fidelity (GO:0106074)cytoplasm (GO:0005737)mitochondrial matrix (GO:0005759)mitochondrial threonyl-tRNA aminoacylation (GO:0070159)mitochondrion (GO:0005739)nucleotide binding (GO:0000166)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)tRNA aminoacylation (GO:0043039)tRNA aminoacylation for protein translation (GO:0006418)threonine-tRNA ligase activity (GO:0004829)threonine-tRNA ligase activity (GO:0004829)threonine-tRNA ligase activity (GO:0004829)threonyl-tRNA aminoacylation (GO:0006435)threonyl-tRNA aminoacylation (GO:0006435)

Expression (TPM)

TFs regulating TARS2 0 TFs

Transcription factors with Perturb-seq knockdown data for TARS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TARS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TARS2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TARS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:150,213,532–150,214,095	273.7 kb	Distal (>10kb) Multiome	441
chr1:150,234,435–150,235,519	252.7 kb	Distal (>10kb) Multiome	725
chr1:150,235,635–150,236,696	251.2 kb	Distal (>10kb) Multiome	905
chr1:150,255,443–150,256,199	231.7 kb	Distal (>10kb) Multiome	441
chr1:150,256,563–150,257,324	230.4 kb	Distal (>10kb) Multiome	223
chr1:150,257,589–150,258,594	229.3 kb	Distal (>10kb) Multiome	233
chr1:150,259,728–150,260,778	227.3 kb	Distal (>10kb) Multiome	362
chr1:150,268,574–150,269,453	218.3 kb	Distal (>10kb) Multiome	785
chr1:150,281,629–150,283,038	205.0 kb	Distal (>10kb) Multiome	503
chr1:150,293,680–150,294,144	193.6 kb	Distal (>10kb) Multiome	755
chr1:150,313,761–150,314,506	173.3 kb	Distal (>10kb) Multiome	108
chr1:150,321,137–150,321,825	165.9 kb	Distal (>10kb) Multiome	806
chr1:150,363,368–150,364,980	123.4 kb	Distal (>10kb) Multiome	971
chr1:150,487,154–150,487,710	76 bp	At TSS Multiome	929
chr1:150,515,085–150,516,227	28.3 kb	Distal (>10kb) Multiome	781
chr1:150,548,849–150,549,823	61.8 kb	Distal (>10kb) Multiome	620
chr1:150,560,828–150,562,623	73.9 kb	Distal (>10kb) Multiome	897
chr1:150,578,554–150,580,300	92.2 kb	Distal (>10kb) Multiome	990
chr1:150,629,012–150,630,122	142.1 kb	Distal (>10kb) Multiome	875
chr1:150,634,804–150,635,486	147.8 kb	Distal (>10kb) Multiome	113
chr1:150,641,008–150,641,820	154.2 kb	Distal (>10kb) Multiome	66
chr1:150,696,984–150,697,716	209.9 kb	Distal (>10kb) Multiome	619
chr1:151,006,389–151,007,024	519.4 kb	Distal (>10kb) Multiome HiCAR	496
chr1:151,008,116–151,008,852	521.0 kb	Distal (>10kb) Multiome HiCAR	763

Genome Browser

Genomic view of the TARS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.