TAOK2
TAO kinase 2 | KIAA0881, MAP3K17, PSK, PSK-1, PSK1, PSK1-BETA, TAO1, TAO2, Tao2beta, hKFC-C

Enables mitogen-activated protein kinase kinase binding activity; neuropilin binding activity; and protein serine/threonine kinase activity. Involved in several processes, including focal adhesion assembly; intracellular signal transduction; and positive regulation of MAPK cascade. Located in cytoplasmic vesicle; cytosol; and nuclear lumen. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 67 terms
ATP binding (GO:0005524)DNA damage response (GO:0006974)MAP kinase kinase kinase activity (GO:0004709)actin cytoskeleton (GO:0015629)actin cytoskeleton (GO:0015629)actin cytoskeleton organization (GO:0030036)apoptotic process (GO:0006915)axon (GO:0030424)axon (GO:0030424)axonal growth cone (GO:0044295)axonal growth cone (GO:0044295)axonogenesis (GO:0007409)axonogenesis (GO:0007409)axonogenesis (GO:0007409)basal dendrite arborization (GO:0150020)basal dendrite arborization (GO:0150020)basal dendrite morphogenesis (GO:0150019)basal dendrite morphogenesis (GO:0150019)cell migration (GO:0016477)cell morphogenesis involved in neuron differentiation (GO:0048667)cytoplasm (GO:0005737)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle membrane (GO:0030659)cytoskeleton (GO:0005856)dendrite (GO:0030425)dendritic growth cone (GO:0044294)dendritic growth cone (GO:0044294)focal adhesion assembly (GO:0048041)mitogen-activated protein kinase kinase binding (GO:0031434)mitotic G2 DNA damage checkpoint signaling (GO:0007095)mitotic G2 DNA damage checkpoint signaling (GO:0007095)neuron projection (GO:0043005)neuron projection (GO:0043005)neuron projection morphogenesis (GO:0048812)neuropilin binding (GO:0038191)neuropilin binding (GO:0038191)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of JNK cascade (GO:0046330)positive regulation of JNK cascade (GO:0046330)positive regulation of JNK cascade (GO:0046330)positive regulation of JNK cascade (GO:0046330)positive regulation of JNK cascade (GO:0046330)positive regulation of JNK cascade (GO:0046330)positive regulation of MAPK cascade (GO:0043410)positive regulation of stress-activated MAPK cascade (GO:0032874)positive regulation of stress-activated MAPK cascade (GO:0032874)positive regulation of stress-activated MAPK cascade (GO:0032874)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activator activity (GO:0043539)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein targeting to membrane (GO:0006612)regulation of actin cytoskeleton organization (GO:0032956)regulation of actin cytoskeleton organization (GO:0032956)regulation of actin cytoskeleton organization (GO:0032956)regulation of cell growth (GO:0001558)regulation of cell shape (GO:0008360)signaling receptor complex (GO:0043235)stress-activated MAPK cascade (GO:0051403)tau protein binding (GO:0048156)tau-protein kinase activity (GO:0050321)
Expression (TPM)
TAOK2 — as a Regulated Gene

TFs regulating TAOK2 0 TFs

Transcription factors with Perturb-seq knockdown data for TAOK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAOK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TAOK2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAOK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:29,678,867–29,679,831 294.6 kb Distal (>10kb) Multiome 783
chr16:29,708,839–29,709,431 264.8 kb Distal (>10kb) Multiome 96
chr16:29,709,743–29,710,091 263.8 kb Distal (>10kb) Multiome 21
chr16:29,784,957–29,785,426 188.6 kb Distal (>10kb) Multiome 452
chr16:29,790,073–29,791,192 183.2 kb Distal (>10kb) Multiome 1003
chr16:29,804,592–29,808,172 168.1 kb Distal (>10kb) Multiome 1275
chr16:29,810,746–29,812,649 161.5 kb Distal (>10kb) Multiome 826
chr16:29,815,828–29,817,186 157.7 kb Distal (>10kb) Multiome 1006
chr16:29,862,597–29,863,901 110.4 kb Distal (>10kb) Multiome 953
chr16:29,876,281–29,878,282 96.2 kb Distal (>10kb) Multiome 319
chr16:29,899,174–29,900,833 74.4 kb Distal (>10kb) Multiome 1019
chr16:29,925,692–29,926,784 47.6 kb Distal (>10kb) Multiome 912
chr16:29,961,477–29,962,530 11.9 kb Distal (>10kb) Multiome 848
chr16:29,973,238–29,974,906 155 bp At TSS Multiome 935
chr16:29,994,888–29,996,728 22.3 kb Distal (>10kb) Multiome 1080
chr16:30,021,215–30,021,860 47.7 kb Distal (>10kb) Multiome 764
chr16:30,052,803–30,053,364 79.2 kb Distal (>10kb) Multiome 989
chr16:30,063,722–30,066,296 90.2 kb Distal (>10kb) Multiome 1209
chr16:30,075,490–30,076,439 102.1 kb Distal (>10kb) Multiome 828
chr16:30,090,881–30,092,910 119.0 kb Distal (>10kb) Multiome 1101
chr16:30,095,557–30,096,839 122.5 kb Distal (>10kb) Multiome 824
chr16:30,122,728–30,123,578 149.4 kb Distal (>10kb) Multiome 718
chr16:30,182,759–30,183,865 209.6 kb Distal (>10kb) Multiome 547

Genome Browser

Genomic view of the TAOK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:29,668,867 – 30,193,865
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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