This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for TAFA5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAFA5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAFA5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:46,803,079–46,803,635 | 1686.1 kb | Distal (>10kb) Multiome HiCAR | 349 | |
| chr22:48,239,500–48,240,631 | 249.2 kb | Distal (>10kb) Multiome | 91 | |
| chr22:48,488,964–48,490,436 | 203 bp | At TSS Multiome | 118 | |
| chr22:48,492,446–48,492,690 | 2.9 kb | Proximal (<10kb) | 123 | |
| chr22:48,574,950–48,575,954 | 85.8 kb | Distal (>10kb) Multiome | 270 | |
| chr22:48,576,060–48,577,208 | 87.3 kb | Distal (>10kb) Multiome | 160 |
Genomic view of the TAFA5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.