Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for TAF1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAF1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAF1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:9,554,934–9,556,567 | 287.6 kb | Distal (>10kb) Multiome | 1091 | |
| chr2:9,630,002–9,631,663 | 212.4 kb | Distal (>10kb) Multiome | 995 | |
| chr2:9,770,260–9,771,096 | 72.8 kb | Distal (>10kb) Multiome | 321 | |
| chr2:9,813,714–9,814,312 | 29.4 kb | Distal (>10kb) Multiome | 406 | |
| chr2:9,843,034–9,844,039 | 45 bp | At TSS Multiome | 965 | |
| chr2:9,950,478–9,952,371 | 108.1 kb | Distal (>10kb) Multiome | 704 | |
| chr2:10,042,279–10,044,590 | 200.7 kb | Distal (>10kb) Multiome | 999 | |
| chr2:10,057,234–10,058,147 | 214.3 kb | Distal (>10kb) Multiome | 504 | |
| chr2:10,079,477–10,080,916 | 236.6 kb | Distal (>10kb) Multiome | 381 | |
| chr2:10,097,234–10,097,850 | 254.1 kb | Distal (>10kb) Multiome | 372 | |
| chr2:10,120,050–10,120,940 | 277.0 kb | Distal (>10kb) Multiome | 1054 | |
| chr2:10,121,967–10,123,307 | 279.2 kb | Distal (>10kb) Multiome | 958 |
Genomic view of the TAF1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.