Predicted to enable neurexin family protein binding activity. Involved in exocytosis. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SYTL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYTL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYTL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:27,102,589–27,103,140 | 239.2 kb | Distal (>10kb) Multiome | 263 | |
| chr1:27,154,381–27,155,711 | 186.9 kb | Distal (>10kb) Multiome | 1038 | |
| chr1:27,233,894–27,235,362 | 107.6 kb | Distal (>10kb) Multiome | 807 | |
| chr1:27,321,904–27,322,688 | 19.9 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:27,332,682–27,333,054 | 9.0 kb | Proximal (<10kb) | 182 | |
| chr1:27,341,872–27,342,076 | at TSS | At TSS | 550 | |
| chr1:27,349,161–27,350,366 | 7.7 kb | Proximal (<10kb) Multiome | 573 | |
| chr1:27,350,548–27,351,814 | 9.3 kb | Proximal (<10kb) Multiome | 387 | |
| chr1:27,357,379–27,358,028 | 15.6 kb | Distal (>10kb) Multiome | 449 | |
| chr1:27,360,338–27,361,256 | 18.5 kb | Distal (>10kb) Multiome | 170 | |
| chr1:27,365,152–27,367,350 | 24.8 kb | Distal (>10kb) Multiome | 748 | |
| chr1:27,382,910–27,383,795 | 41.3 kb | Distal (>10kb) Multiome | 234 | |
| chr1:27,391,473–27,393,056 | 50.5 kb | Distal (>10kb) Multiome | 700 | |
| chr1:27,489,673–27,490,714 | 148.2 kb | Distal (>10kb) Multiome | 978 | |
| chr1:27,526,947–27,528,904 | 185.3 kb | Distal (>10kb) Multiome | 804 | |
| chr1:27,536,779–27,537,308 | 195.0 kb | Distal (>10kb) Multiome | 160 | |
| chr1:27,556,820–27,557,711 | 215.2 kb | Distal (>10kb) Multiome | 511 | |
| chr1:27,568,200–27,569,231 | 226.6 kb | Distal (>10kb) Multiome | 554 | |
| chr1:27,574,996–27,576,410 | 234.0 kb | Distal (>10kb) Multiome | 587 | |
| chr1:27,592,703–27,593,619 | 251.0 kb | Distal (>10kb) Multiome | 100 | |
| chr1:27,602,169–27,605,005 | 262.1 kb | Distal (>10kb) Multiome | 726 | |
| chr1:27,606,947–27,607,757 | 265.4 kb | Distal (>10kb) Multiome | 620 | |
| chr1:27,614,890–27,615,294 | 273.1 kb | Distal (>10kb) Multiome HiCAR | 84 |
Genomic view of the SYTL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.