The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for SYT6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYT6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYT6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:113,904,394–113,905,850 | 248.7 kb | Distal (>10kb) Multiome | 1025 | |
| chr1:113,929,054–113,930,528 | 224.3 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:113,978,866–113,979,713 | 174.5 kb | Distal (>10kb) Multiome | 426 | |
| chr1:114,037,114–114,037,804 | 116.6 kb | Distal (>10kb) Multiome HiCAR | 57 | |
| chr1:114,152,319–114,153,141 | 1.1 kb | Proximal (<10kb) Multiome | 229 | |
| chr1:114,153,412–114,154,525 | 972 bp | At TSS | 213 | |
| chr1:114,154,905–114,155,303 | 2.5 kb | Proximal (<10kb) | 162 | |
| chr1:114,345,893–114,347,057 | 192.7 kb | Distal (>10kb) Multiome | 785 |
Genomic view of the SYT6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.