Predicted to be involved in chemical synaptic transmission. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SYPL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYPL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYPL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:105,849,145–105,849,924 | 262.7 kb | Distal (>10kb) Multiome | 308 | |
| chr7:105,876,091–105,877,586 | 235.6 kb | Distal (>10kb) Multiome | 773 | |
| chr7:105,962,909–105,963,831 | 149.0 kb | Distal (>10kb) Multiome | 169 | |
| chr7:105,990,565–105,991,288 | 121.4 kb | Distal (>10kb) Multiome | 112 | |
| chr7:106,009,291–106,010,280 | 102.6 kb | Distal (>10kb) Multiome | 640 | |
| chr7:106,042,587–106,043,289 | 69.4 kb | Distal (>10kb) Multiome | 430 | |
| chr7:106,111,676–106,113,209 | 43 bp | At TSS Multiome | 968 | |
| chr7:106,176,499–106,177,243 | 64.5 kb | Distal (>10kb) Multiome | 473 | |
| chr7:106,283,900–106,286,008 | 172.9 kb | Distal (>10kb) Multiome | 996 |
Genomic view of the SYPL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.