SUPT4H1

SPT4 homolog, DSIF elongation factor subunit | SPT4H, Spt4, Supt4a, SUPT4H

This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Member of: DE-1 DE-1.51 Developmental clusters: GC5

Biological processes 23 terms

DSIF complex (GO:0032044)DSIF complex (GO:0032044)RNA polymerase II complex binding (GO:0000993)RNA polymerase inhibitor activity (GO:0140870)negative regulation of DNA-templated transcription, elongation (GO:0032785)negative regulation of DNA-templated transcription, elongation (GO:0032785)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription, elongation (GO:0032786)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of transcription elongation by RNA polymerase II (GO:0034243)transcription elongation by RNA polymerase II (GO:0006368)transcription elongation by RNA polymerase II (GO:0006368)transcription elongation-coupled chromatin remodeling (GO:0140673)transcription pausing by RNA polymerase II (GO:0160239)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating SUPT4H1 0 TFs

Transcription factors with Perturb-seq knockdown data for SUPT4H1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUPT4H1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SUPT4H1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUPT4H1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:58,082,555–58,084,952	268.9 kb	Distal (>10kb) Multiome	835
chr17:58,156,945–58,157,756	195.0 kb	Distal (>10kb) Multiome	235
chr17:58,218,800–58,219,654	132.9 kb	Distal (>10kb) Multiome	890
chr17:58,249,147–58,250,121	102.5 kb	Distal (>10kb) Multiome	737
chr17:58,324,153–58,325,169	27.6 kb	Distal (>10kb) Multiome	274
chr17:58,338,012–58,338,430	14.0 kb	Distal (>10kb) Multiome	559
chr17:58,339,009–58,339,515	12.9 kb	Distal (>10kb) Multiome	382
chr17:58,351,751–58,352,762	132 bp	At TSS Multiome	990
chr17:58,353,050–58,353,260	849 bp	At TSS	246
chr17:58,487,466–58,488,518	135.6 kb	Distal (>10kb) Multiome	222
chr17:58,513,911–58,515,157	162.4 kb	Distal (>10kb) Multiome	585
chr17:58,517,239–58,519,377	165.8 kb	Distal (>10kb) Multiome	1140
chr17:58,527,884–58,528,411	176.0 kb	Distal (>10kb) Multiome	79
chr17:58,531,392–58,532,430	179.8 kb	Distal (>10kb) Multiome	323
chr17:58,630,482–58,632,252	279.5 kb	Distal (>10kb) Multiome	1257

Genome Browser

Genomic view of the SUPT4H1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.