This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for SUGT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUGT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUGT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:52,449,904–52,451,090 | 202.1 kb | Distal (>10kb) Multiome | 972 | |
| chr13:52,454,948–52,456,258 | 197.2 kb | Distal (>10kb) Multiome | 791 | |
| chr13:52,599,686–52,600,643 | 52.4 kb | Distal (>10kb) Multiome | 545 | |
| chr13:52,617,038–52,617,928 | 35.3 kb | Distal (>10kb) Multiome | 723 | |
| chr13:52,651,967–52,653,338 | 50 bp | At TSS Multiome | 966 | |
| chr13:52,738,655–52,740,130 | 86.3 kb | Distal (>10kb) Multiome | 284 | |
| chr13:52,845,321–52,849,096 | 196.0 kb | Distal (>10kb) Multiome HiCAR | 495 | |
| chr13:52,850,131–52,851,975 | 199.1 kb | Distal (>10kb) Multiome | 871 | |
| chr13:52,906,206–52,906,789 | 253.8 kb | Distal (>10kb) Multiome | 87 | |
| chr13:53,190,934–53,191,826 | 538.6 kb | Distal (>10kb) Multiome HiCAR | 177 |
Genomic view of the SUGT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.