SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003]
Transcription factors with Perturb-seq knockdown data for SUGP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUGP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUGP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:19,032,820–19,034,059 | 286.8 kb | Distal (>10kb) Multiome | 944 | |
| chr19:19,063,253–19,064,386 | 256.7 kb | Distal (>10kb) Multiome | 781 | |
| chr19:19,105,310–19,106,514 | 214.8 kb | Distal (>10kb) Multiome | 447 | |
| chr19:19,110,429–19,110,857 | 209.8 kb | Distal (>10kb) Multiome | 131 | |
| chr19:19,119,998–19,121,362 | 200.0 kb | Distal (>10kb) Multiome | 304 | |
| chr19:19,138,171–19,138,698 | 182.0 kb | Distal (>10kb) Multiome | 642 | |
| chr19:19,170,055–19,170,692 | 150.1 kb | Distal (>10kb) Multiome | 403 | |
| chr19:19,191,912–19,193,209 | 127.9 kb | Distal (>10kb) Multiome | 939 | |
| chr19:19,202,895–19,203,773 | 117.0 kb | Distal (>10kb) Multiome | 599 | |
| chr19:19,224,938–19,225,553 | 95.3 kb | Distal (>10kb) Multiome | 646 | |
| chr19:19,261,403–19,261,973 | 58.8 kb | Distal (>10kb) Multiome | 205 | |
| chr19:19,272,869–19,273,464 | 47.4 kb | Distal (>10kb) Multiome | 236 | |
| chr19:19,320,030–19,321,531 | 178 bp | At TSS Multiome | 839 | |
| chr19:19,384,944–19,386,424 | 65.1 kb | Distal (>10kb) Multiome | 788 | |
| chr19:19,405,072–19,406,890 | 85.2 kb | Distal (>10kb) Multiome | 1014 | |
| chr19:19,461,886–19,462,726 | 141.8 kb | Distal (>10kb) Multiome | 345 | |
| chr19:19,515,735–19,516,510 | 195.7 kb | Distal (>10kb) Multiome | 824 | |
| chr19:19,532,119–19,532,674 | 211.9 kb | Distal (>10kb) Multiome | 405 | |
| chr19:19,538,087–19,538,726 | 217.8 kb | Distal (>10kb) Multiome | 255 | |
| chr19:19,539,681–19,541,846 | 220.9 kb | Distal (>10kb) Multiome | 352 | |
| chr19:19,575,151–19,576,000 | 255.1 kb | Distal (>10kb) Multiome | 128 | |
| chr19:19,618,285–19,619,315 | 298.3 kb | Distal (>10kb) Multiome | 414 |
Genomic view of the SUGP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.