SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SUDS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUDS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUDS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:118,103,306–118,104,597 | 272.6 kb | Distal (>10kb) Multiome | 730 | |
| chr12:118,119,571–118,120,301 | 256.8 kb | Distal (>10kb) Multiome HiCAR | 62 | |
| chr12:118,120,669–118,121,341 | 255.6 kb | Distal (>10kb) Multiome HiCAR | 428 | |
| chr12:118,135,872–118,136,757 | 240.5 kb | Distal (>10kb) Multiome HiCAR | 914 | |
| chr12:118,371,358–118,372,072 | 4.5 kb | Proximal (<10kb) | 296 | |
| chr12:118,372,364–118,373,361 | 3.5 kb | Proximal (<10kb) Multiome | 792 | |
| chr12:118,376,094–118,377,029 | 156 bp | At TSS Multiome | 844 | |
| chr12:118,520,842–118,521,879 | 144.9 kb | Distal (>10kb) Multiome | 16 |
Genomic view of the SUDS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.