Predicted to be involved in positive regulation of collagen biosynthetic process; positive regulation of osteoblast differentiation; and regulation of bone remodeling. Predicted to be located in rough endoplasmic reticulum. Predicted to be active in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SUCO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUCO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUCO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:172,278,274–172,278,975 | 254.4 kb | Distal (>10kb) Multiome | 172 | |
| chr1:172,360,503–172,361,306 | 172.4 kb | Distal (>10kb) Multiome | 314 | |
| chr1:172,443,641–172,444,611 | 89.0 kb | Distal (>10kb) Multiome | 880 | |
| chr1:172,531,992–172,534,273 | 190 bp | At TSS Multiome | 997 | |
| chr1:172,537,930–172,538,246 | 4.8 kb | Proximal (<10kb) | 102 | |
| chr1:172,544,331–172,545,606 | 11.9 kb | Distal (>10kb) Multiome | 138 | |
| chr1:172,559,459–172,560,699 | 26.9 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the SUCO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.