Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SUCLA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUCLA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUCLA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:46,796,424–46,797,697 | 1204.2 kb | Distal (>10kb) Multiome HiCAR | 930 | |
| chr13:46,893,895–46,894,720 | 1107.1 kb | Distal (>10kb) Multiome HiCAR | 352 | |
| chr13:48,000,679–48,002,503 | 48 bp | At TSS Multiome | 801 | |
| chr13:48,004,207–48,005,023 | 2.9 kb | Proximal (<10kb) | 30 | |
| chr13:48,037,295–48,039,275 | 36.5 kb | Distal (>10kb) Multiome | 1096 | |
| chr13:48,094,468–48,095,500 | 93.8 kb | Distal (>10kb) Multiome | 866 | |
| chr13:48,232,588–48,234,160 | 231.9 kb | Distal (>10kb) Multiome | 750 |
Genomic view of the SUCLA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.