Enables armadillo repeat domain binding activity; enzyme binding activity; and protein-macromolecule adaptor activity. Involved in negative regulation of hippo signaling; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; nucleoplasm; and plasma membrane. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STRN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STRN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STRN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:30,822,055–30,822,752 | 204.1 kb | Distal (>10kb) Multiome | 275 | |
| chr14:30,873,914–30,876,058 | 151.9 kb | Distal (>10kb) Multiome | 887 | |
| chr14:31,025,320–31,027,211 | 204 bp | At TSS Multiome | 1060 | |
| chr14:31,029,422–31,029,650 | 3.0 kb | Proximal (<10kb) | 47 | |
| chr14:31,030,968–31,031,141 | 4.6 kb | Proximal (<10kb) | 8 | |
| chr14:31,038,509–31,039,198 | 12.4 kb | Distal (>10kb) Multiome | 498 | |
| chr14:31,059,276–31,059,946 | 33.4 kb | Distal (>10kb) Multiome | 491 | |
| chr14:31,060,184–31,060,800 | 34.1 kb | Distal (>10kb) Multiome | 152 | |
| chr14:31,206,827–31,208,656 | 181.5 kb | Distal (>10kb) Multiome | 1146 |
Genomic view of the STRN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.