This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for STRIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STRIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STRIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:109,739,695–109,740,873 | 294.4 kb | Distal (>10kb) Multiome | 633 | |
| chr1:109,877,325–109,877,790 | 157.1 kb | Distal (>10kb) Multiome | 378 | |
| chr1:109,910,465–109,911,472 | 123.8 kb | Distal (>10kb) Multiome | 618 | |
| chr1:109,931,127–109,931,638 | 103.3 kb | Distal (>10kb) Multiome | 379 | |
| chr1:109,959,723–109,960,843 | 74.1 kb | Distal (>10kb) Multiome | 464 | |
| chr1:109,984,134–109,985,352 | 49.9 kb | Distal (>10kb) Multiome | 946 | |
| chr1:110,003,773–110,004,806 | 30.4 kb | Distal (>10kb) Multiome | 517 | |
| chr1:110,029,619–110,030,057 | 4.6 kb | Proximal (<10kb) | 192 | |
| chr1:110,034,238–110,035,409 | 106 bp | At TSS Multiome | 824 | |
| chr1:110,067,875–110,068,495 | 33.5 kb | Distal (>10kb) Multiome | 113 | |
| chr1:110,068,868–110,070,694 | 36.0 kb | Distal (>10kb) Multiome | 149 | |
| chr1:110,106,008–110,106,637 | 71.7 kb | Distal (>10kb) Multiome | 311 | |
| chr1:110,134,868–110,135,830 | 100.8 kb | Distal (>10kb) Multiome | 133 | |
| chr1:110,150,271–110,151,323 | 116.0 kb | Distal (>10kb) Multiome | 278 | |
| chr1:110,209,629–110,212,414 | 175.6 kb | Distal (>10kb) Multiome | 639 | |
| chr1:110,300,420–110,301,012 | 266.1 kb | Distal (>10kb) Multiome | 100 | |
| chr1:110,312,453–110,313,110 | 278.2 kb | Distal (>10kb) Multiome | 331 |
Genomic view of the STRIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.