Involved in positive regulation of apoptotic process and positive regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STPG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STPG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STPG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:24,150,246–24,151,570 | 263.1 kb | Distal (>10kb) Multiome | 480 | |
| chr1:24,186,980–24,187,928 | 226.3 kb | Distal (>10kb) Multiome | 546 | |
| chr1:24,321,723–24,322,705 | 91.4 kb | Distal (>10kb) Multiome | 514 | |
| chr1:24,413,280–24,414,095 | 5 bp | At TSS Multiome | 627 | |
| chr1:24,415,211–24,416,076 | 1.9 kb | Proximal (<10kb) Multiome | 686 | |
| chr1:24,502,196–24,503,523 | 89.2 kb | Distal (>10kb) Multiome | 663 | |
| chr1:24,506,950–24,507,727 | 93.5 kb | Distal (>10kb) Multiome | 119 | |
| chr1:24,642,448–24,643,922 | 229.4 kb | Distal (>10kb) Multiome | 942 | |
| chr1:24,705,111–24,705,985 | 291.8 kb | Distal (>10kb) Multiome | 599 | |
| chr1:24,713,638–24,714,105 | 300.2 kb | Distal (>10kb) Multiome | 23 |
Genomic view of the STPG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.