This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STEAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STEAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STEAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:88,306,373–88,307,266 | 1904.9 kb | Distal (>10kb) Multiome HiCAR | 312 | |
| chr7:90,153,881–90,154,994 | 57.2 kb | Distal (>10kb) Multiome | 605 | |
| chr7:90,210,927–90,212,730 | 12 bp | At TSS Multiome | 843 | |
| chr7:90,223,993–90,224,776 | 12.7 kb | Distal (>10kb) Multiome | 109 | |
| chr7:90,244,257–90,246,748 | 33.5 kb | Distal (>10kb) Multiome | 850 | |
| chr7:90,345,490–90,347,070 | 135.0 kb | Distal (>10kb) Multiome | 940 | |
| chr7:90,403,221–90,404,177 | 191.9 kb | Distal (>10kb) Multiome | 843 |
Genomic view of the STEAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.