Predicted to be located in membrane. Predicted to be active in endosome and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STEAP1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STEAP1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STEAP1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:22,319,900–22,320,510 | 180.0 kb | Distal (>10kb) Multiome | 131 | |
| chr7:22,356,400–22,357,987 | 143.0 kb | Distal (>10kb) Multiome | 577 | |
| chr7:22,452,174–22,452,922 | 47.7 kb | Distal (>10kb) Multiome | 396 | |
| chr7:22,477,712–22,479,056 | 22.0 kb | Distal (>10kb) Multiome | 137 | |
| chr7:22,499,925–22,500,379 | 2 bp | At TSS Multiome | 271 | |
| chr7:22,549,622–22,550,567 | 50.1 kb | Distal (>10kb) Multiome | 336 | |
| chr7:22,703,088–22,703,942 | 203.3 kb | Distal (>10kb) Multiome | 251 | |
| chr7:22,708,694–22,710,118 | 209.2 kb | Distal (>10kb) Multiome | 287 | |
| chr7:22,782,701–22,783,430 | 282.9 kb | Distal (>10kb) Multiome | 163 |
Genomic view of the STEAP1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.