This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:173,055,699–173,057,854 | 271.2 kb | Distal (>10kb) Multiome | 1049 | |
| chr5:173,144,311–173,145,555 | 183.7 kb | Distal (>10kb) Multiome | 967 | |
| chr5:173,234,580–173,235,384 | 93.5 kb | Distal (>10kb) Multiome | 307 | |
| chr5:173,245,361–173,246,026 | 82.7 kb | Distal (>10kb) Multiome | 109 | |
| chr5:173,283,642–173,284,193 | 44.5 kb | Distal (>10kb) Multiome | 911 | |
| chr5:173,293,791–173,294,435 | 34.3 kb | Distal (>10kb) Multiome | 433 | |
| chr5:173,327,090–173,330,477 | 1.3 kb | Proximal (<10kb) Multiome | 1064 | |
| chr5:173,332,058–173,332,283 | 3.6 kb | Proximal (<10kb) | 527 | |
| chr5:173,615,977–173,617,113 | 288.3 kb | Distal (>10kb) Multiome | 845 |
Genomic view of the STC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.