Transcription factors with Perturb-seq knockdown data for STARD4-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STARD4-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STARD4-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:111,223,414–111,225,205 | 287.9 kb | Distal (>10kb) Multiome | 593 | |
| chr5:111,447,496–111,448,355 | 64.3 kb | Distal (>10kb) Multiome | 259 | |
| chr5:111,511,588–111,513,437 | 363 bp | At TSS Multiome | 1035 | |
| chr5:111,548,011–111,549,940 | 36.5 kb | Distal (>10kb) Multiome | 416 | |
| chr5:111,756,861–111,758,380 | 245.4 kb | Distal (>10kb) Multiome | 939 | |
| chr5:112,160,273–112,161,560 | 648.6 kb | Distal (>10kb) Multiome HiCAR | 1064 | |
| chr5:112,165,948–112,167,034 | 654.3 kb | Distal (>10kb) Multiome HiCAR | 403 |
Genomic view of the STARD4-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.