ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ST6GALNAC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST6GALNAC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST6GALNAC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:75,785,522–75,786,824 | 288.6 kb | Distal (>10kb) Multiome | 835 | |
| chr1:76,071,472–76,071,942 | 2.8 kb | Proximal (<10kb) | 40 | |
| chr1:76,072,783–76,073,182 | 1.6 kb | Proximal (<10kb) | 27 | |
| chr1:76,074,255–76,075,430 | 33 bp | At TSS Multiome | 452 | |
| chr1:76,082,134–76,082,844 | 7.4 kb | Proximal (<10kb) | 51 | |
| chr1:76,867,296–76,869,405 | 793.5 kb | Distal (>10kb) Multiome HiCAR | 480 | |
| chr1:77,281,467–77,283,407 | 1208.3 kb | Distal (>10kb) Multiome HiCAR | 488 | |
| chr1:77,888,069–77,889,521 | 1814.0 kb | Distal (>10kb) Multiome HiCAR | 648 |
Genomic view of the ST6GALNAC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.