This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for ST3GAL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST3GAL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST3GAL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:126,061,736–126,063,712 | 292.6 kb | Distal (>10kb) Multiome | 802 | |
| chr11:126,082,403–126,083,132 | 273.0 kb | Distal (>10kb) Multiome | 134 | |
| chr11:126,104,267–126,104,892 | 251.1 kb | Distal (>10kb) Multiome | 192 | |
| chr11:126,159,698–126,160,582 | 195.6 kb | Distal (>10kb) Multiome | 281 | |
| chr11:126,210,869–126,212,282 | 144.1 kb | Distal (>10kb) Multiome | 846 | |
| chr11:126,268,478–126,269,613 | 86.7 kb | Distal (>10kb) Multiome | 828 | |
| chr11:126,282,310–126,283,787 | 72.6 kb | Distal (>10kb) Multiome | 754 | |
| chr11:126,303,694–126,304,639 | 51.6 kb | Distal (>10kb) Multiome | 979 | |
| chr11:126,345,823–126,346,956 | 9.3 kb | Proximal (<10kb) Multiome | 446 | |
| chr11:126,355,100–126,356,405 | 9 bp | At TSS Multiome | 596 | |
| chr11:126,440,475–126,441,596 | 85.3 kb | Distal (>10kb) Multiome | 367 | |
| chr11:126,480,538–126,481,044 | 125.2 kb | Distal (>10kb) Multiome | 487 | |
| chr11:126,497,641–126,499,015 | 142.8 kb | Distal (>10kb) Multiome | 250 | |
| chr11:126,502,215–126,503,760 | 147.5 kb | Distal (>10kb) Multiome | 129 | |
| chr11:126,606,944–126,608,877 | 251.9 kb | Distal (>10kb) Multiome | 412 |
Genomic view of the ST3GAL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.