The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for SSR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:156,455,670–156,456,078 | 99.3 kb | Distal (>10kb) Multiome | 220 | |
| chr3:156,456,730–156,457,712 | 98.0 kb | Distal (>10kb) Multiome | 238 | |
| chr3:156,554,637–156,555,736 | 63 bp | At TSS Multiome | 851 | |
| chr3:156,605,674–156,606,640 | 50.9 kb | Distal (>10kb) Multiome | 453 | |
| chr3:156,628,812–156,629,757 | 74.2 kb | Distal (>10kb) Multiome | 108 | |
| chr3:156,673,773–156,675,967 | 119.2 kb | Distal (>10kb) Multiome | 1144 | |
| chr3:156,739,496–156,740,549 | 184.9 kb | Distal (>10kb) Multiome | 99 | |
| chr3:156,815,908–156,817,589 | 261.8 kb | Distal (>10kb) Multiome | 769 | |
| chr3:156,825,909–156,827,101 | 271.2 kb | Distal (>10kb) Multiome | 901 | |
| chr3:157,129,802–157,131,179 | 575.5 kb | Distal (>10kb) Multiome HiCAR | 724 | |
| chr3:157,142,157–157,142,920 | 587.4 kb | Distal (>10kb) Multiome HiCAR | 171 | |
| chr3:157,159,206–157,161,193 | 605.1 kb | Distal (>10kb) Multiome HiCAR | 1215 |
Genomic view of the SSR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.