SSR2

signal sequence receptor subunit 2 | TLAP, TRAPB

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]

Member of: DE-1

Biological processes 9 terms

cotranslational protein targeting to membrane (GO:0006613)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)membrane (GO:0016020)membrane (GO:0016020)post-translational protein targeting to membrane, translocation (GO:0031204)protein binding (GO:0005515)

Expression (TPM)

TFs regulating SSR2 0 TFs

Transcription factors with Perturb-seq knockdown data for SSR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SSR2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:155,745,339–155,745,870	275.3 kb	Distal (>10kb) Multiome	505
chr1:155,806,537–155,807,073	214.1 kb	Distal (>10kb) Multiome	15
chr1:155,856,932–155,857,529	163.7 kb	Distal (>10kb) Multiome	639
chr1:155,859,095–155,860,745	161.5 kb	Distal (>10kb) Multiome	632
chr1:155,910,686–155,911,579	109.6 kb	Distal (>10kb) Multiome	691
chr1:155,934,107–155,934,787	86.5 kb	Distal (>10kb) Multiome	872
chr1:155,976,727–155,977,187	44.0 kb	Distal (>10kb) Multiome	316
chr1:155,977,296–155,979,264	42.2 kb	Distal (>10kb) Multiome	698
chr1:156,020,469–156,021,128	13 bp	At TSS Multiome	558
chr1:156,025,989–156,026,181	5.1 kb	Proximal (<10kb)	262
chr1:156,052,923–156,055,358	33.9 kb	Distal (>10kb) Multiome	1053
chr1:156,060,806–156,061,738	40.3 kb	Distal (>10kb) Multiome HiCAR	318
chr1:156,063,507–156,064,184	42.9 kb	Distal (>10kb) Multiome HiCAR	199
chr1:156,076,488–156,077,355	56.1 kb	Distal (>10kb) Multiome	246
chr1:156,081,942–156,083,586	61.7 kb	Distal (>10kb) Multiome	670
chr1:156,105,879–156,107,316	85.6 kb	Distal (>10kb) Multiome	663
chr1:156,114,184–156,115,669	93.8 kb	Distal (>10kb) Multiome	824
chr1:156,123,520–156,124,091	102.9 kb	Distal (>10kb) Multiome	679
chr1:156,129,945–156,130,610	109.5 kb	Distal (>10kb) Multiome	733
chr1:156,146,058–156,146,760	125.4 kb	Distal (>10kb) Multiome	429
chr1:156,149,593–156,150,242	129.1 kb	Distal (>10kb) Multiome	194
chr1:156,160,602–156,161,218	140.1 kb	Distal (>10kb) Multiome	218
chr1:156,181,487–156,182,119	160.8 kb	Distal (>10kb) Multiome	145
chr1:156,184,002–156,185,155	163.5 kb	Distal (>10kb) Multiome	216
chr1:156,193,531–156,194,375	173.0 kb	Distal (>10kb) Multiome	751
chr1:156,212,611–156,213,686	192.2 kb	Distal (>10kb) Multiome	893
chr1:156,245,413–156,246,269	224.8 kb	Distal (>10kb) Multiome	380
chr1:156,282,165–156,283,323	261.9 kb	Distal (>10kb) Multiome	973
chr1:156,291,233–156,291,857	270.6 kb	Distal (>10kb) Multiome	518

Genome Browser

Genomic view of the SSR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.