The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for SSR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:6,686,589–6,687,652 | 626.1 kb | Distal (>10kb) Multiome HiCAR | 601 | |
| chr6:7,041,267–7,042,109 | 271.6 kb | Distal (>10kb) Multiome | 263 | |
| chr6:7,050,934–7,052,927 | 261.3 kb | Distal (>10kb) Multiome | 552 | |
| chr6:7,106,611–7,109,813 | 205.5 kb | Distal (>10kb) Multiome | 938 | |
| chr6:7,140,630–7,141,553 | 172.0 kb | Distal (>10kb) Multiome | 863 | |
| chr6:7,173,710–7,174,435 | 139.3 kb | Distal (>10kb) Multiome | 276 | |
| chr6:7,183,372–7,184,225 | 129.3 kb | Distal (>10kb) Multiome | 129 | |
| chr6:7,260,713–7,262,501 | 51.8 kb | Distal (>10kb) Multiome | 852 | |
| chr6:7,312,560–7,313,754 | 37 bp | At TSS Multiome | 1075 | |
| chr6:7,347,359–7,348,352 | 34.6 kb | Distal (>10kb) Multiome | 256 | |
| chr6:7,389,283–7,390,343 | 76.6 kb | Distal (>10kb) Multiome | 1040 | |
| chr6:7,541,127–7,543,319 | 228.3 kb | Distal (>10kb) Multiome HiCAR | 970 | |
| chr6:7,548,319–7,549,268 | 235.5 kb | Distal (>10kb) Multiome HiCAR | 504 | |
| chr6:7,589,842–7,590,956 | 277.0 kb | Distal (>10kb) Multiome | 877 | |
| chr6:7,615,396–7,616,491 | 302.8 kb | Distal (>10kb) Multiome HiCAR | 297 |
Genomic view of the SSR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.