This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for SSH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:29,566,006–29,569,574 | 192.8 kb | Distal (>10kb) Multiome | 868 | |
| chr17:29,572,746–29,573,303 | 188.5 kb | Distal (>10kb) Multiome | 252 | |
| chr17:29,588,688–29,590,312 | 171.8 kb | Distal (>10kb) Multiome | 590 | |
| chr17:29,590,975–29,592,562 | 169.6 kb | Distal (>10kb) Multiome | 810 | |
| chr17:29,612,906–29,613,942 | 147.8 kb | Distal (>10kb) Multiome | 581 | |
| chr17:29,614,997–29,616,357 | 145.7 kb | Distal (>10kb) Multiome | 389 | |
| chr17:29,616,988–29,618,466 | 143.2 kb | Distal (>10kb) Multiome | 615 | |
| chr17:29,622,374–29,623,287 | 138.5 kb | Distal (>10kb) Multiome | 470 | |
| chr17:29,761,028–29,761,644 | 18 bp | At TSS Multiome | 643 | |
| chr17:29,929,376–29,930,689 | 168.8 kb | Distal (>10kb) Multiome | 768 | |
| chr17:29,930,801–29,930,957 | 525 bp | At TSS | 86 | |
| chr17:30,104,595–30,105,065 | 343.4 kb | Distal (>10kb) Multiome | 585 | |
| chr17:30,116,470–30,117,077 | 355.4 kb | Distal (>10kb) Multiome | 800 |
Genomic view of the SSH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.