SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
Transcription factors with Perturb-seq knockdown data for SSBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:141,511,342–141,512,397 | 226.3 kb | Distal (>10kb) Multiome | 217 | |
| chr7:141,550,725–141,551,853 | 187.0 kb | Distal (>10kb) Multiome | 899 | |
| chr7:141,584,907–141,585,342 | 153.2 kb | Distal (>10kb) Multiome | 149 | |
| chr7:141,701,501–141,702,649 | 36.2 kb | Distal (>10kb) Multiome | 455 | |
| chr7:141,733,513–141,733,674 | 4.7 kb | Proximal (<10kb) | 14 | |
| chr7:141,737,828–141,738,838 | 92 bp | At TSS Multiome | 1117 | |
| chr7:141,975,843–141,976,803 | 238.0 kb | Distal (>10kb) Multiome | 357 | |
| chr7:141,994,100–141,994,957 | 256.3 kb | Distal (>10kb) Multiome | 70 |
Genomic view of the SSBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.