This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for SRSF10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRSF10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRSF10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:23,691,587–23,692,258 | 288.6 kb | Distal (>10kb) Multiome | 876 | |
| chr1:23,742,958–23,744,137 | 237.0 kb | Distal (>10kb) Multiome | 802 | |
| chr1:23,777,908–23,778,814 | 202.0 kb | Distal (>10kb) Multiome | 849 | |
| chr1:23,790,777–23,791,448 | 189.2 kb | Distal (>10kb) Multiome | 637 | |
| chr1:23,799,493–23,801,538 | 179.5 kb | Distal (>10kb) Multiome | 922 | |
| chr1:23,825,075–23,825,633 | 154.9 kb | Distal (>10kb) Multiome | 867 | |
| chr1:23,867,741–23,868,918 | 112.0 kb | Distal (>10kb) Multiome | 766 | |
| chr1:23,958,982–23,960,271 | 20.6 kb | Distal (>10kb) Multiome | 1051 | |
| chr1:23,979,815–23,981,031 | 1 bp | At TSS Multiome | 1078 | |
| chr1:23,998,624–23,999,076 | 18.5 kb | Distal (>10kb) Multiome | 19 | |
| chr1:24,150,246–24,151,570 | 170.3 kb | Distal (>10kb) Multiome | 480 | |
| chr1:24,186,980–24,187,928 | 207.0 kb | Distal (>10kb) Multiome | 546 |
Genomic view of the SRSF10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.