SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]
Transcription factors with Perturb-seq knockdown data for SRRM4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRRM4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRRM4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:118,979,838–118,980,345 | 1.6 kb | Proximal (<10kb) | 139 | |
| chr12:118,980,947–118,982,158 | 42 bp | At TSS Multiome | 277 | |
| chr12:119,008,284–119,009,257 | 27.3 kb | Distal (>10kb) Multiome HiCAR | 144 | |
| chr12:119,068,638–119,069,299 | 87.6 kb | Distal (>10kb) Multiome | 39 | |
| chr12:119,089,271–119,089,712 | 107.8 kb | Distal (>10kb) Multiome | 81 | |
| chr12:119,090,372–119,091,307 | 109.4 kb | Distal (>10kb) Multiome | 53 | |
| chr12:119,153,337–119,154,993 | 172.2 kb | Distal (>10kb) Multiome | 247 | |
| chr12:119,178,270–119,179,483 | 197.0 kb | Distal (>10kb) Multiome | 281 | |
| chr12:119,202,226–119,202,817 | 221.0 kb | Distal (>10kb) Multiome | 45 |
Genomic view of the SRRM4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.