SRR

serine racemase | ILV1, ISO1

Enables several functions, including L-serine ammonia-lyase activity; PDZ domain binding activity; and heterocyclic compound binding activity. Involved in carboxylic acid metabolic process and response to lipopolysaccharide. Located in cytoplasm and neuronal cell body. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5 Developmental clusters: GC6

Biological processes 46 terms

ATP binding (GO:0005524)ATP binding (GO:0005524)ATP binding (GO:0005524)ATP binding (GO:0005524)D-serine ammonia-lyase activity (GO:0008721)D-serine biosynthetic process (GO:0070179)D-serine biosynthetic process (GO:0070179)D-serine biosynthetic process (GO:0070179)L-serine ammonia-lyase activity (GO:0003941)L-serine ammonia-lyase activity (GO:0003941)L-serine ammonia-lyase activity (GO:0003941)L-serine metabolic process (GO:0006563)L-serine metabolic process (GO:0006563)PDZ domain binding (GO:0030165)amino acid metabolic process (GO:0006520)apical part of cell (GO:0045177)calcium ion binding (GO:0005509)calcium ion binding (GO:0005509)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)glycine binding (GO:0016594)glycine binding (GO:0016594)identical protein binding (GO:0042802)identical protein binding (GO:0042802)magnesium ion binding (GO:0000287)magnesium ion binding (GO:0000287)magnesium ion binding (GO:0000287)metal ion binding (GO:0046872)neuronal cell body (GO:0043025)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)pyridoxal phosphate binding (GO:0030170)pyridoxal phosphate binding (GO:0030170)pyridoxal phosphate binding (GO:0030170)pyridoxal phosphate binding (GO:0030170)pyruvate biosynthetic process (GO:0042866)response to ketamine (GO:1901986)response to lipopolysaccharide (GO:0032496)response to xenobiotic stimulus (GO:0009410)serine racemase activity (GO:0030378)serine racemase activity (GO:0030378)serine racemase activity (GO:0030378)threonine racemase activity (GO:0018114)threonine racemase activity (GO:0018114)

Expression (TPM)

TFs regulating SRR 0 TFs

Transcription factors with Perturb-seq knockdown data for SRR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SRR

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:2,023,483–2,024,229	280.2 kb	Distal (>10kb) Multiome	281
chr17:2,024,769–2,026,284	278.5 kb	Distal (>10kb) Multiome	459
chr17:2,029,741–2,030,885	273.1 kb	Distal (>10kb) Multiome	871
chr17:2,041,423–2,042,366	262.0 kb	Distal (>10kb) Multiome	834
chr17:2,048,764–2,051,218	254.9 kb	Distal (>10kb) Multiome	658
chr17:2,053,643–2,054,179	250.2 kb	Distal (>10kb) Multiome	473
chr17:2,054,616–2,055,766	248.9 kb	Distal (>10kb) Multiome	544
chr17:2,058,401–2,059,503	245.1 kb	Distal (>10kb) Multiome	366
chr17:2,302,778–2,304,288	248 bp	At TSS Multiome	770
chr17:2,336,166–2,337,712	32.5 kb	Distal (>10kb) Multiome	896
chr17:2,392,290–2,394,855	88.9 kb	Distal (>10kb) Multiome	788
chr17:2,396,361–2,397,494	93.0 kb	Distal (>10kb) Multiome	546
chr17:2,398,260–2,402,837	95.7 kb	Distal (>10kb) Multiome	1128
chr17:2,511,517–2,512,317	208.0 kb	Distal (>10kb) Multiome	698
chr17:2,592,971–2,594,792	289.7 kb	Distal (>10kb) Multiome	853

Genome Browser

Genomic view of the SRR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.