This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for SRP72. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRP72 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRP72, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:56,323,870–56,324,663 | 143.3 kb | Distal (>10kb) Multiome | 70 | |
| chr4:56,386,710–56,387,993 | 80.2 kb | Distal (>10kb) Multiome | 942 | |
| chr4:56,434,804–56,437,263 | 31.7 kb | Distal (>10kb) Multiome | 1056 | |
| chr4:56,467,264–56,468,300 | 39 bp | At TSS Multiome | 743 | |
| chr4:56,505,059–56,505,907 | 37.9 kb | Distal (>10kb) Multiome | 306 | |
| chr4:56,530,151–56,531,207 | 62.9 kb | Distal (>10kb) Multiome | 395 | |
| chr4:56,544,602–56,545,190 | 77.2 kb | Distal (>10kb) Multiome | 720 | |
| chr4:56,655,262–56,656,591 | 188.1 kb | Distal (>10kb) Multiome | 237 |
Genomic view of the SRP72 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.