Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in cytosol; nuclear body; and nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRP19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRP19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRP19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:112,707,010–112,708,233 | 153.7 kb | Distal (>10kb) Multiome | 823 | |
| chr5:112,710,793–112,712,214 | 149.9 kb | Distal (>10kb) Multiome | 154 | |
| chr5:112,737,494–112,738,559 | 123.5 kb | Distal (>10kb) Multiome | 697 | |
| chr5:112,848,068–112,848,715 | 12.8 kb | Distal (>10kb) Multiome | 275 | |
| chr5:112,860,721–112,861,653 | 40 bp | At TSS Multiome | 948 | |
| chr5:112,920,841–112,922,670 | 60.0 kb | Distal (>10kb) Multiome | 913 | |
| chr5:112,976,029–112,977,339 | 115.4 kb | Distal (>10kb) Multiome | 889 |
Genomic view of the SRP19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.